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FRIDAY, March 27, 2020 (HealthDay News) — Prenatal and perinatal factors may influence a child’s risk for developing psychosis, according to a review and meta-analysis published online March 24 in The Lancet Psychiatry<\/i>.<\/p>\n
Cathy Davies, Ph.D., from King’s College London, and colleagues conducted a systematic literature review to identify studies evaluating the association between prenatal or perinatal risk and protective factors and psychotic disorders.<\/p>\n
The researchers identified 152 eligible studies evaluating 98 risk or protective factors. Significant risk factors were: maternal age <20 years (odds ratio [OR], 1.17) or 30 to 34 years (OR, 1.05); paternal age <20 years (OR, 1.31) and >35 years (OR, 1.28); any maternal (OR, 4.60) or paternal (OR, 2.73) psychopathology; maternal psychosis (OR, 7.61) and affective disorder (OR, 2.26); three or more pregnancies (OR, 1.30); herpes simplex 2 (OR, 1.35); maternal infections not otherwise specified (NOS; OR, 1.27); suboptimal number of antenatal visits (OR, 1.83); winter (OR, 1.05) and winter to spring (OR, 1.05) season of birth in the northern hemisphere; maternal stress NOS (OR, 2.40); any famine or nutritional deficits in pregnancy (OR, 1.40); maternal hypertension (OR, 1.40); hypoxia (OR, 1.63); ruptured (OR, 1.86) and premature rupture (OR, 2.29) of membranes; polyhydramnios (OR, 3.05); definite obstetric complications NOS (OR, 1.83); birthweights <2,000 g (OR, 1.84), <2,500 g (OR 153), or 2,500 to 2,999 g (OR, 1.23); birth length <49 cm (OR, 1.17); small for gestational age (OR, 1.40); premature birth (OR, 1.35); and congenital malformations (OR, 2.35). Significant protective factors were fewer and included maternal ages 20 to 24 years (OR, 0.93) and 25 to 29 years (OR, 0.92); nulliparity (OR, 0.91); and birthweights 3,500 to 3,999 g (OR, 0.90) or >4,000 g (OR, 0.86).<\/p>\n
“The updated knowledge emerging from this study could refine understanding of psychosis pathogenesis, enhance multivariable risk prediction, and inform preventive strategies,” the authors write.<\/p>\n
One author disclosed ties to a pharmaceutical company.<\/p>\n
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