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FRIDAY, March 13, 2020 (HealthDay News) — Patients with psoriasis may have a slightly increased risk for cancer, according to a review published online Feb. 19 in JAMA Dermatology<\/i>.<\/p>\n
Sofie Vaengebjerg, M.D., from University of Copenhagen in Denmark, and colleagues evaluated the association between cancer risk and psoriasis or psoriatic arthritis.<\/p>\n
Based on 112 included studies (total 2,053,932 patients), the researchers found that the overall prevalence of cancer in patients with psoriasis was 4.78 percent (95 percent confidence interval [CI], 4.02 to 5.59 percent), with an incidence rate of 11.75 per 1,000 person-years (95 percent CI, 8.66 to 15.31) and a risk ratio (RR) of 1.21 (95 percent CI, 1.11 to 1.33). Increased risk was seen for several cancers, including keratinocyte cancer (RR, 2.28; 95 percent CI, 1.73 to 3.01), lymphomas (RR, 1.56; 95 percent CI, 1.37 to 1.78), lung cancer (RR, 1.26; 95 percent CI, 1.13 to 1.40), and bladder cancer (RR, 1.12; 95 percent CI, 1.04 to 1.19). For patients with psoriasis treated with biologic agents, there was no increased risk for cancer (RR, 0.97; 95 percent CI, 0.85 to 1.10). There was no association between psoriatic arthritis and increased risk for cancer overall (RR, 1.02; 95 percent CI, 0.97 to 1.08).<\/p>\n
“Clinicians treating patients with psoriasis should be aware of this increased risk, especially for lymphomas, as immunogenic treatment might be associated with exacerbations,” the authors write.<\/p>\n
Several authors disclosed ties to the pharmaceutical industry.<\/p>\n
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