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FRIDAY, Feb. 21, 2020 (HealthDay News) — Socioeconomic position is inversely associated with standardized incidence of lupus nephritis and antineutrophil cytoplasmic antibody-related glomerulonephritis (ANCA-GN), according to a study published online Feb. 20 in the Clinical Journal of the American Society of Nephrology<\/i>.<\/p>\n
Mark Canney, Ph.D., from the University of British Columbia in Vancouver, Canada, and colleagues conducted a retrospective cohort study to capture all incident cases of membranous nephropathy, immunoglobulin A (IgA) nephropathy, focal segmental glomerulosclerosis (FSGS), ANCA-GN, and lupus nephritis (392, 818, 375, 387, and 389, respectively) in a provincial kidney pathology database. The authors examined the relationship between socioeconomic position and incidence of glomerular diseases.<\/p>\n
The researchers identified a graded increase in standardized incidence with lower income for lupus nephritis and ANCA-GN. The lowest versus highest income quintile had a standardized rate ratio of 1.7 in women with lupus nephritis and 1.5 in ANCA-GN. A less consistent association was seen between income and FSGS; only the lowest income quintile was associated with higher disease incidence (standardized rate ratio, 1.55). For IgA nephropathy or membranous nephropathy, there were no significant associations noted.<\/p>\n
“An improved understanding of socioeconomic determinants of glomerular disease could inform future research regarding disease pathogenesis, as well as health policy directed toward vulnerable populations at increased risk of organ-threatening autoimmune diseases,” the authors write.<\/p>\n
One author disclosed financial ties to the biopharmaceutical industry.<\/p>\n
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