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MONDAY, April 2, 2018 (HealthDay News) — For children with retinitis pigmentosa, vitamin A supplementation is associated with slower loss of cone electroretinogram amplitude, according to a study published online March 29 in JAMA Ophthalmology<\/i>.<\/p>\n
Eliot L. Berson, M.D., from Harvard Medical School in Boston, and colleagues conducted a nonrandomized comparison study involving children with retinitis pigmentosa taking or not taking vitamin A supplementation (55 and 25, respectively). The main outcome was the mean exponential rates of change of full-field cone electroretinogram amplitude to 30-Hz flashes.<\/p>\n
The researchers found that in the unadjusted model, the estimated mean rates of change were \u22120.0713 loge<\/sub> unit\/year for the vitamin A cohort and \u22120.1419 loge<\/sub> unit per year for the control cohort (\u22126.9 and \u221213.2 percent per year, respectively). A slower mean rate of decline was confirmed in the vitamin A cohort in the adjusted model (difference, 0.0771 loge<\/sub>-unit per year). There was no difference by cohort in the mean exponential rates of change of visual field area and visual acuity and the incidences of falling to a visual field diameter of 20 degrees or less or a visual acuity of 20\/200 or less in at least one eye.<\/p>\n “A vitamin A palmitate supplement was associated with a slower loss of cone electroretinogram amplitude in children with retinitis pigmentosa,” the authors write.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n