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Here are what the editors at HealthDay consider to be the most important developments in Pathology for March 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.<\/p>\n
Novel Metabolites Provide Insight to Health Benefits of Coffee<\/font><\/p>\n FRIDAY, March 30, 2018 (HealthDay News) — Metabolomic profiling highlights potential mechanisms to explain coffee’s health effects, according to a study published online March 15 in the Journal of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Rate of MI, Stroke Higher After Respiratory Infection<\/font><\/p>\n FRIDAY, March 30, 2018 (HealthDay News) — The risk for myocardial infarction (MI) or stroke remains higher after laboratory-confirmed Streptococcus pneumoniae<\/i> or influenza, according to a study published March 21 in the European Respiratory Journal<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Montreal Parkinson Risk of Dementia Scale Deemed Accurate<\/font><\/p>\n FRIDAY, March 30, 2018 (HealthDay News) — The office-based, eight-item Montreal Parkinson Risk of Dementia Scale is a valid predictor of development of dementia, according to a study published online March 26 in JAMA Neurology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Lag in Progress Against Lung CA Mortality in Midwest, Appalachia<\/font><\/p>\n FRIDAY, March 30, 2018 (HealthDay News) — In the Midwest and Appalachia there are areas where progress against lung cancer mortality among women is lagging compared with the rest of the nation, according to a study published March 30 in Cancer Epidemiology, Biomarkers & Prevention<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Non-Invasive Test Can Detect Urothelial Cancer<\/font><\/p>\n THURSDAY, March 29, 2018 (HealthDay News) — UroSEEK, which uses DNA recovered from cells shed into urine, can detect urothelial cancer, according to a study published online March 20 in eLife<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Islet Transplantation Improves Quality of Life in T1DM<\/font><\/p>\n THURSDAY, March 29, 2018 (HealthDay News) — There are significant improvements in health-related quality of life (HRQOL) following islet transplantation in patients with type 1 diabetes complicated by severe hypoglycemia, according to a study published online March 21 in Diabetes Care<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Novel Interstitium Has Been Identified in Human Tissues<\/font><\/p>\n THURSDAY, March 29, 2018 (HealthDay News) — A previously unrecognized interstitium has been identified in human tissues, according to a study published online March 27 in Scientific Reports<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Relapse in Major Depression Linked to Brain Cortical Changes<\/font><\/p>\n THURSDAY, March 29, 2018 (HealthDay News) — For patients with major depressive disorder (MDD), relapse is associated with brain cortical changes over two years, according to a study published online March 28 in JAMA Psychiatry<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Molecular Minimal Disease in Remission Predicts AML Relapse<\/font><\/p>\n WEDNESDAY, March 28, 2018 (HealthDay News) — The detection of molecular minimal residual disease is associated with increased relapse rates in acute myeloid leukemia (AML), according to a study published in the March 29 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Liquids in E-Cigarettes Are Heterogeneous, Frequently Toxic<\/font><\/p>\n WEDNESDAY, March 28, 2018 (HealthDay News) — The e-liquids used in electronic cigarettes (e-cigarettes) are a heterogeneous group, and there is a positive correlation between the number of chemicals contained in the liquid and the likelihood of its toxicity, according to a study published online March 27 in PLOS Biology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Reduced Overall Survival for Alcohol-Related Liver Cancer<\/font><\/p>\n WEDNESDAY, March 28, 2018 (HealthDay News) — Reduced overall survival (OS) is seen for patients with alcohol-related hepatocellular carcinoma (HCC), according to a study published online March 28 in Cancer<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n 1980 to 2014 Saw Decrease in U.S. Mortality From Infectious Diseases<\/font><\/p>\n TUESDAY, March 27, 2018 (HealthDay News) — There were declines in mortality from most categories of infectious diseases between 1980 and 2014 in the United States, according to a study published in the March 27 issue of the Journal of the American Medical Association<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n EHR Usability Contributes to Possible Patient Harm Events<\/font><\/p>\n TUESDAY, March 27, 2018 (HealthDay News) — Electronic health record (EHR) usability may contribute to possible patient harm events, according to a research letter published in the March 27 issue of the Journal of the American Medical Association<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Amygdala Neurons Reduced in Adulthood With Autism<\/font><\/p>\n TUESDAY, March 27, 2018 (HealthDay News) — In neurotypical development, there is an increase in the number of mature neurons in the basal and accessory basal nuclei, whereas an initial excess of amygdala neurons is seen during childhood in autism spectrum disorder (ASD), followed by a reduction in adulthood, according to a study published online March 20 in the Proceedings of the National Academy of Sciences<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Hepatitis C Screening Increasing Among Baby Boomers<\/font><\/p>\n TUESDAY, March 27, 2018 (HealthDay News) — For baby boomers, born between 1945 and 1965, the odds of hepatitis C virus (HCV) screening increase over time, although the rates of screening are low, according to a study published online March 27 in Cancer Epidemiology, Biomarkers & Prevention<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Complete Genome Sequence Can Be ID’d From Amniotic Fluid<\/font><\/p>\n TUESDAY, March 27, 2018 (HealthDay News) — The complete genome sequence of fetuses can be elucidated from amniotic fluid, according to a study published online March 15 in Clinical Chemistry<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text<\/a><\/p>\n Ethical Duties ID’d for Short-Term Global Health Experiences<\/font><\/p>\n MONDAY, March 26, 2018 (HealthDay News) — In a position paper published online March 27 in the Annals of Internal Medicine<\/i>, ethical obligations have been detailed for physicians participating in short-term global health experiences (STEGHs).<\/p>\n Abstract\/Full Text<\/a><\/p>\n Vigil Immunotherapy Tolerated Well for Recurrent Ovarian CA Tx<\/font><\/p>\n MONDAY, March 26, 2018 (HealthDay News) — Vigil immunotherapy shows good tolerability for recurrent ovarian cancer patients, and PARP 7, a poly(ADP-ribose) polymerase protein, may play a significant role in survival for ovarian cancer, according to two studies presented at the Society of Gynecologic Oncology’s Annual Meeting on Women’s Cancer, held from March 24 to 27 in New Orleans.<\/p>\n Abstracts<\/a><\/p>\n More Information<\/a><\/p>\n Genetic Assay of PAP Tests May Help Dx Endometrial, Ovarian CA<\/font><\/p>\n MONDAY, March 26, 2018 (HealthDay News) — PapSEEK, which incorporates assays for mutations in 18 genes and for aneuploidy in DNA recovered from fluids obtained during a routine Pap test, may aid in detection of endometrial and ovarian cancers, according to a study published online March 21 in Science Translational Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n BMI Linked to Hepatocellular Carcinoma Risk in Chronic Hep B<\/font><\/p>\n MONDAY, March 26, 2018 (HealthDay News) — For patients with chronic hepatitis B virus (HBV), body mass index (BMI) is significantly associated with increased risk of hepatocellular carcinoma (HCC), with the risk more pronounced for women than men, according to a research letter published online March 22 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Lean Approach May Help Tackle Burnout in Health Care Providers<\/font><\/p>\n FRIDAY, March 23, 2018 (HealthDay News) — The Lean approach, which emphasizes reducing waste and improving customer value by focusing on the big picture, can be used to address physician burnout, according to a report published in Medical Economics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Neural Markers of Depression Resilience ID’d in Female Teens<\/font><\/p>\n FRIDAY, March 23, 2018 (HealthDay News) — Adolescent females at high familial risk of depression who do not go on to develop depression have compensatory functional connectivity patterns in emotion regulatory networks, according to a study published online March 21 in JAMA Psychiatry<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Calorie Restriction Linked to Sustained Metabolic Adaptation<\/font><\/p>\n THURSDAY, March 22, 2018 (HealthDay News) — Calorie restriction (CR) over two years is associated with considerable weight loss, and with lower than expected energy expenditure (EE) relative to the weight loss, according to a study published online March 22 in Cell Metabolism<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Unique Risks Associated With Texting Medical Orders<\/font><\/p>\n THURSDAY, March 22, 2018 (HealthDay News) — Despite the popularity, convenience, and speed of texting medical orders, there are unique and alarming risks associated with the practice, according to a report published in Drug Topics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Dipeptidyl Peptidase-4 Inhibitors in T2DM Linked to IBD<\/font><\/p>\n THURSDAY, March 22, 2018 (HealthDay News) — Dipeptidyl peptidase-4 (DPP-4) inhibitors are associated with increased risk of inflammatory bowel disease among patients with type 2 diabetes, according to a study published online March 21 in The BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Hydrochlorothiazide Tied to Non-Melanoma Skin Cancer Risk<\/font><\/p>\n THURSDAY, March 22, 2018 (HealthDay News) — Use of the diuretic hydrochlorothiazide is associated with a substantially increased risk of non-melanoma skin cancer, according to a study published in the April issue of the Journal of the American Academy of Dermatology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Soy-Based Formula Tied to Reproductive Differences<\/font><\/p>\n THURSDAY, March 22, 2018 (HealthDay News) — Infants given soy-based formula have reproductive system differences compared with those given cow-milk formula or breast milk, according to a study published online March 1 in the Journal of Clinical Endocrinology & Metabolism<\/i>.<\/p>\n Abstract\/ Full Text (subscription or payment may be required)<\/a><\/p>\n H. Pylori<\/i> Treatment Tied to Lower Metachronous Gastric Cancer Risk<\/font><\/p>\n WEDNESDAY, March 21, 2018 (HealthDay News) — Antibiotic treatment for Helicobacter pylori<\/i> (H. pylori<\/i>) in patients who underwent endoscopic resection of early-stage gastric cancer or high-grade adenoma is associated with a reduced rate of metachronous gastric cancer, according to a study published in the March 22 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n HIV Incidence Down in All Except Men Who Have Sex With Men<\/font><\/p>\n WEDNESDAY, March 21, 2018 (HealthDay News) — From 2008 to 2015, there was a decrease in modeled HIV incidence in all transmission risk groups except men who have sex with men (MSM), according to research published online March 20 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Cardiovascular Health Declining in the United States<\/font><\/p>\n WEDNESDAY, March 21, 2018 (HealthDay News) — Trends in racial\/ethnic and nativity disparities in cardiovascular health decreased from 1988 to 2014, with the decrease attributed to worsening cardiovascular health among whites, according to a study published online March 20 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Oxyntomodulin Augments Glucose Homeostasis <\/font><\/p>\n WEDNESDAY, March 21, 2018 (HealthDay News) — In obese subjects with and without type 2 diabetes mellitus (T2DM), oxyntomodulin (OXM) significantly augments glucose-dependent insulin secretion, according to a study published online March 15 in Diabetes<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Blueprint Being Developed to Address Physician Burnout<\/font><\/p>\n WEDNESDAY, March 21, 2018 (HealthDay News) — A new, three-pronged approach is being applied to develop a blueprint for addressing physician burnout, according to a report published in Medical Economics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Personal Health Info Found in Recycling at Five Hospitals<\/font><\/p>\n TUESDAY, March 20, 2018 (HealthDay News) — A considerable amount of personal health information (PHI) and personally identifiable information (PII) was found in the recycling at five Canadian teaching hospitals, according to a research letter published in the March 20 issue of the Journal of the American Medical Association<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment nay be required)<\/a><\/p>\n In-Flight Transmission of Respiratory Diseases Low<\/font><\/p>\n TUESDAY, March 20, 2018 (HealthDay News) — The probability of direct transmission of respiratory diseases is low for passengers on transcontinental U.S. flights not seated in close proximity to an infectious passenger, according to a study published online March 19 in the Proceedings of the National Academy of Sciences<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Tamoxifen, Raloxifene Linked to Improvements in MD in Mice<\/font><\/p>\n TUESDAY, March 20, 2018 (HealthDay News) — Tamoxifen and raloxifene are associated with improvements in muscular dystrophy caused by mutations of the Fukutin-related protein (FKRP<\/i>) gene in a mouse model, according to a study published in the April issue of The American Journal of Pathology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment nay be required)<\/a><\/p>\n Prior Authorization Negatively Impacts Clinical Outcomes<\/font><\/p>\n MONDAY, March 19, 2018 (HealthDay News) — The burdens associated with prior authorization (PA) are high and include a negative impact on clinical outcomes, reported by 92 percent of physicians, according to the results of a survey conducted for the American Medical Association (AMA).<\/p>\n Press Release<\/a><\/p>\n Survey<\/a><\/p>\n Reduced Cortical Thickness ID’d in Obstructive Sleep Apnea<\/font><\/p>\n FRIDAY, March 16, 2018 (HealthDay News) — Reduced cortical thickness is seen in individuals with obstructive sleep apnea (OSA) versus controls, with multiple regions of reduced thickness seen in the superior frontal lobe in females with OSA, according to a study published online March 6 in PLOS ONE<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Higher Burden of Trichomonas vaginalis<\/i> Infection in U.S. Blacks<\/font><\/p>\n FRIDAY, March 16, 2018 (HealthDay News) — The burden of Trichomonas vaginalis<\/i> (TV) infection is disproportionately high among blacks in the United States, according to a study published online March 15 in Clinical Infectious Diseases<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n BMI As Predictor of CVD Risk May Be More Susceptible to Bias<\/font><\/p>\n FRIDAY, March 16, 2018 (HealthDay News) — The J-shaped correlation seen for body mass index (BMI) with cardiovascular disease (CVD) risk is susceptible to confounding due to pre-existing comorbidities, according to a study published online March 15 in the European Heart Journal<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Hep C Compounds Alcoholism’s Effect on Brain Volume<\/font><\/p>\n FRIDAY, March 16, 2018 (HealthDay News) — Alcohol dependence has deleterious effects on frontal cortical volumes that are compounded by hepatitis C virus (HCV) infection and drug dependence, according to a study published online March 14 in JAMA Psychiatry<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Barriers to Colorectal Cancer Screening Among Poor Identified<\/font><\/p>\n THURSDAY, March 14, 2018 (HealthDay News) — Improving colorectal cancer screening rates among lower-income populations requires addressing structural, personal, and health care system barriers, according to research published in the April issue of Diseases of the Colon & Rectum<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Grilled Meat, Chicken Ups Risk of Type 2 Diabetes in U.S. Adults<\/font><\/p>\n THURSDAY, March 15, 2018 (HealthDay News) — Open-flame and\/or high-temperature cooking methods (such as grilling\/barbecuing, broiling, or roasting) to prepare chicken and red meat are associated with an increased risk of type 2 diabetes (T2D), according to a study published online March 12 in Diabetes Care<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Gut Bacteria May Be Tied to Brain Dysfunction From Sepsis<\/font><\/p>\n THURSDAY, March 15, 2018 (HealthDay News) — Gut bacteria may be tied to sepsis-related brain dysfunction, according to a study published recently in the American Journal of Respiratory and Critical Care Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Fewer SIDS Cases Result From Genetic Heart Disease Causes<\/font><\/p>\n THURSDAY, March 15, 2018 (HealthDay News) — Genetic heart diseases (GHDs) cause fewer cases of sudden infant death syndrome (SIDS) than previously thought, according to a study published in the March 20 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Higher Exposure to Air Pollution Adds to CVD Risk for Blacks<\/font><\/p>\n THURSDAY, March 15, 2018 (HealthDay News) — Blacks have significantly higher exposure to ambient fine particulate matter (particles with median aerodynamic diameter <2.5 \u00b5m [PM2.5<\/sub>]), with exposure associated with elevated blood glucose, worse endothelial function, and incident cardiovascular disease (CVD), according to a study published online March 15 in Arteriosclerosis, Thrombosis, and Vascular Biology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Zika-Tied Birth Defects in 7 Percent of Infected Pregnant Women<\/font><\/p>\n WEDNESDAY, March 14, 2018 (HealthDay News) — Seven percent of pregnant women with symptomatic Zika virus (ZIKV) infection have birth defects possibly associated with ZIKV infection, according to a study published in the March 15 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Too Few Early Breast CA Patients Given Formal Genetic Counseling<\/font><\/p>\n WEDNESDAY, March 14, 2018 (HealthDay News) — Many women with early-stage breast cancer with indications for formal genetic risk evaluation do not receive formal counseling, according to a study published online March 12 in the Journal of Clinical Oncology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n U.S. Spends Twice As Much for Similar Health Care Utilization<\/font><\/p>\n TUESDAY, March 13, 2018 (HealthDay News) — Spending on health care is much higher in the United States than other high-income countries, but utilization rates are similar, according to a study published in the March 13 issue of the Journal of the American Medical Association<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial 1 (subscription or payment may be required)<\/a><\/p>\n Editorial 2 (subscription or payment may be required)<\/a><\/p>\n Editorial 3 (subscription or payment may be required)<\/a><\/p>\n Editorial 4 (subscription or payment may be required)<\/a><\/p>\n IL-6 Levels Predict Response to ECT in Depressive Disorder<\/font><\/p>\n TUESDAY, March 13, 2018 (HealthDay News) — For patients with major depressive disorder, interleukin-6 (IL-6) may predict benefit from electroconvulsive therapy (ECT), according to a study published recently in the Journal of Clinical Psychiatry<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Low-Level Lead Exposure Ups CVD Mortality Risk in U.S. Adults<\/font><\/p>\n TUESDAY, March 13, 2018 (HealthDay News) — Environmental lead exposure is a risk factor for all-cause, cardiovascular disease, and ischemic heart disease mortality, according to a study published online March 12 in The Lancet Public Health<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Excessive Daytime Sleepiness Tied to Increased \u03b2-Amyloid<\/font><\/p>\n TUESDAY, March 13, 2018 (HealthDay News) — Baseline excessive daytime sleepiness (EDS) is associated with increased \u03b2-amyloid (A\u03b2) accumulation in elderly individuals without dementia, according to a study published online March 12 in JAMA Neurology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n