{"id":30696,"date":"2020-01-31T00:00:00","date_gmt":"2020-01-31T00:00:00","guid":{"rendered":"http:\/\/medgoo.com\/index.php\/2020\/01\/31\/reirradiation-rarely-required-in-focal-rt-for-multiple-myeloma\/"},"modified":"2020-02-03T17:10:11","modified_gmt":"2020-02-03T17:10:11","slug":"reirradiation-rarely-required-in-focal-rt-for-multiple-myeloma","status":"publish","type":"post","link":"https:\/\/medgoo.com\/index.php\/2020\/01\/31\/reirradiation-rarely-required-in-focal-rt-for-multiple-myeloma\/","title":{"rendered":"Reirradiation Rarely Required in Focal RT for Multiple Myeloma"},"content":{"rendered":"<h3>For biologically effective dose &#8804;28 Gy<sub>10<\/sub>, small but significant increase seen in reirradiation rates<\/h3>\n<p><b><\/b><\/p>\n<p><b><\/b><\/p>\n<p>FRIDAY, Jan. 31, 2020 (HealthDay News) &#8212; For patients with multiple myeloma receiving focal radiation therapy (RT) for symptomatic plasmacytoma, reirradiation is rarely required, according to a letter to the editor published online Jan. 9 in <i>Haematologica<\/i>.<\/p>\n<p>Adnan Elhammali, M.D., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues identified all patients aged \u226518 years with a diagnosis of multiple myeloma who were treated with RT from 1999 through 2017. A total of 772 patients treated with RT to 1,513 sites were included; patients were followed for a median of 65.6 months.<\/p>\n<p>The researchers found that the most commonly treated site was the spine (39.4 percent); most patients were treated at a single site (55.9 percent), while 22.9 and 21.4 percent were treated at two sites and three or more sites, respectively. The median biologically effective dose (BED) was 28.8 Gy<sub>10<\/sub>. Overall, 2.6 percent of the 1,513 sites treated underwent reirradiation, with the most common reasons being persistent pain and radiographic progression (90 and 80 percent, respectively). A small but statistically significant increase in reirradiation rates was seen for a BED \u226428 Gy<sub>10<\/sub> (3.25 versus 1.83 percent; hazard ratio, 6.16). After completion of the first course of RT, the median overall survival was 25.6 months, and the one-, three-, and five-year overall survival rates were 66.5, 42.0, and 33.5 percent, respectively.<\/p>\n<p>&#8220;Dose escalation to a BED of at least 28 Gy is recommended when durable local control is desired,&#8221; the authors write.<\/p>\n<p><a href=\"https:\/\/www.haematologica.org\/content\/early\/2020\/01\/03\/haematol.2019.235804\" target=\"_new\" rel=\"noopener noreferrer\">Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n<p><i><\/i><\/p>\n<p><i>Copyright \u00a9 2020 <a href=\"https:\/\/www.healthday.com\/\" target=\"_new\" rel=\"noopener noreferrer\">HealthDay<\/a>. All rights reserved.<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>For biologically effective dose &#8804;28 Gy<sub>10<\/sub>, small but significant increase seen in reirradiation rates<\/p>\n","protected":false},"author":6,"featured_media":30714,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[11],"class_list":["post-30696","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news"],"_links":{"self":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/30696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/comments?post=30696"}],"version-history":[{"count":0,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/30696\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media\/30714"}],"wp:attachment":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media?parent=30696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/categories?post=30696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/tags?post=30696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}