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MONDAY, Jan. 27, 2020 (HealthDay News) — For vitamin D-deficient overweight and obese children, high-dose supplementation with vitamin D does not improve measures of arterial endothelial function or stiffness, but it does result in reductions in blood pressure (BP) and fasting glucose concentration, according to a study published online Jan. 17 in The American Journal of Clinical Nutrition<\/i>.<\/p>\n
Kumaravel Rajakumar, M.D., from the University of Pittsburgh School of Medicine, and colleagues examined whether supplementation with vitamin D3<\/sub> 1,000 or 2,000 IU\/day is more effective than 600 IU\/day for improving arterial endothelial function, arterial stiffness, central and systemic BP, insulin sensitivity, fasting glucose concentration, and lipid profile in 225 vitamin D-deficient overweight and obese children (aged 10 to 18 years).<\/p>\n The researchers observed no difference between children receiving 1,000 or 2,000 IU\/day and those receiving 600 IU\/day in the changes at three and six months in endothelial function, arterial stiffness, systemic-systolic BP, lipids, and inflammatory markers. There were some between-group differences noted in secondary outcomes. At six months, central-systolic, central-diastolic, and systemic-diastolic BP were lower in the 1,000-IU versus the 600-IU group (\u22122.66, \u22123.57, and \u22123.28 mm Hg, respectively). In the 2,000-IU group, insulin sensitivity increased at three and six months and fasting glucose concentration decreased at six months (\u22122.67 mg\/dL).<\/p>\n “Vitamin D status optimization, through its beneficial effects on BP and glucose homeostasis, may have a primary preventive role in improving the long-term cardiovascular health of overweight and obese children,” the authors write.<\/p>\n One author disclosed financial ties to Quest Diagnostics.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n