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FRIDAY, Jan. 24, 2020 (HealthDay News) — Structural features of kidneys from living donors may predict death-censored graft failure in recipients, according to a study published online Jan. 23 in the Journal of the American Society of Nephrology<\/i>.<\/p>\n
Naim Issa, M.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues examined donated kidney features as predictors of death-censored graft failure at three transplant centers using computed tomography and implantation biopsy. Data were analyzed from 2,293 donor-recipient pairs.<\/p>\n
The researchers found there were 287 death-censored graft failures and 424 deaths during a mean recipient follow-up of 6.3 years. Independent of both donor and recipient clinical characteristics, factors that predicted death-censored graft failure included interstitial fibrosis\/tubular atrophy, larger cortical nephron size (but not nephron number), and smaller medullary volume. Arteriolar hyalinosis also predicted death-censored graft failure in a subset with 12 biopsy section slides.<\/p>\n
“We think that these subtle features in the living donor kidney make the recipient more susceptible to lose the kidney transplant over time,” Issa said in a statement. “These important findings may provide insights into previously unrecognized predictors of kidney transplant failure in recipients.”<\/p>\n
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