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FRIDAY, March 30, 2018 (HealthDay News) — Metabolomic profiling highlights potential mechanisms to explain coffee’s health effects, according to a study published online March 15 in the Journal of Internal Medicine<\/i>.<\/p>\n
Marilyn C. Cornelis, Ph.D., from Northwestern University in Chicago, and colleagues conducted nontargeted metabolomic profiling among 47 habitual coffee consumers following three phases: refraining from drinking coffee for one month, consuming four cups of coffee\/day in the second month, and drinking eight cups\/day in the third month.<\/p>\n
The researchers identified 115 metabolites that were significantly associated with coffee intake (P < 0.05). Eighty-two were previously known and mapped to one of 33 predefined biological pathways. However, there was significant enrichment of metabolite members of five pathways (P < 0.05), including xanthine metabolism (caffeine metabolites), benzoate metabolism (reflects polyphenol metabolite products of gut microbiota metabolism), steroid (may reflect phytosterol content of coffee), fatty acid metabolism (acylcholine, a novel link to coffee), and endocannabinoid (also a novel link to coffee).<\/p>\n
“The novel metabolites and candidate pathways we have identified may provide new insight into the mechanisms by which coffee may be exerting its health effects,” the authors write.<\/p>\n
Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n