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THURSDAY, Jan. 9, 2020 (HealthDay News) — Untreated chronic oral infection is not associated with post-hematopoietic stem cell transplant (HSCT) outcomes, according to a study published online Dec. 18 in PLOS ONE<\/i>.<\/p>\n
Matti Mauramo, D.D.M., from the University of Helsinki, and colleagues examined the associations of common oral infections with survival and infectious complications in HSCT recipients in a retrospective case-control study. All 341 allogeneic and 125 autologous HSCT recipients transplanted in a single institution between 2008 and 2016 and referred to oral infection control pre-HSCT were included.<\/p>\n
The researchers found that 14 percent of the allogeneic and 3 percent of the autologous recipients died within six months after HSCT. There was no association noted for oral foci of infections (acute or chronic); decayed, missing, or filled tooth index; or periodontitis pre-HSCT with survival at six months post-HSCT. There were also no associations seen for oral foci of infections with hospital-treated infectious diseases or blood culture-positive bacteremia during follow-up. No association was seen for untreated oral foci of infections with survival or severe infectious complications within six months post-HSCT.<\/p>\n
“Based on our results, it seems that radical and extensive procedures to treat oral infections are not necessary before stem cell transplantations,” Mauramo said in a statement. “Instead, such treatment can be postponed until after the transplantation.”<\/p>\n