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TUESDAY, Dec. 31, 2019 (HealthDay News) — Individuals with objectively-defined subtle cognitive difficulties (Obj-SCD) have faster amyloid accumulation and faster entorhinal cortical thinning compared with cognitively normal (CN) individuals, according to a study published online Dec. 30 in Neurology<\/i>.<\/p>\n
Kelsey R. Thomas, Ph.D., from the University of California, San Diego, School of Medicine in La Jolla, and colleagues examined the temporal sequence of Obj-SCD in relation to amyloidosis and neurodegeneration among 747 Alzheimer’s Disease Neuroimaging Initiative participants (305 CN, 153 Obj-SCD, and 289 with mild cognitive impairment [MCI]). The authors examined the four-year rate of change in cortical 18<\/sup>F-florbetapir positron emission tomography, entorhinal cortex thickness, and hippocampal volume.<\/p>\n The researchers found that compared with the CN group, the Obj-SCD group had faster amyloid accumulation; no significant difference was seen between the MCI and CN groups. Faster entorhinal cortical thinning was seen in the Obj-SCD and MCI groups versus the CN group; compared with CN participants, only the MCI group exhibited faster hippocampal atrophy.<\/p>\n “The current findings suggest that Obj-SCD is also a sensitive and noninvasive predictor of future amyloid accumulation and early neurodegenerative changes, prior to frank cognitive impairment consistent with MCI,” the authors write.<\/p>\n The Alzheimer’s Disease Neuroimaging Initiative is partially funded by multiple biopharmaceutical companies; one author serves as a consultant for several pharmaceutical companies.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n