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TUESDAY, Dec. 31, 2019 (HealthDay News) — The incidence of early-onset gastric cancer has been increasing in the United States, and it seems to be distinct clinically and genetically from late-onset gastric cancer, according to a study recently published in Surgery<\/i>.<\/p>\n
John R. Bergquist, M.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues examined clinical and genomic characteristics and risk factors for early-onset versus late-onset gastric cancer using data from the Surveillance, Epidemiology, and End Results database (1973 to 2015), the Behavioral Risk Factor Surveillance Survey, and The Cancer Genome Atlas.<\/p>\n
The researchers found that during the study period, the incidence of early-onset gastric cancer increased, now comprising more than 30 percent of all gastric cancer in the United States. Compared with late-onset disease, early-onset gastric cancer was associated with higher grade (55.2 versus 46.9 percent), signet-ring cells (19.0 versus 10.4 percent), diffuse histology (25.7 versus 15.0 percent), and metastatic disease (49.5 versus 40.9 percent). Late-onset gastric cancer was more likely to be microsatellite instability subtype (18.6 versus 5.6 percent), whereas early-onset disease was more likely to be Epstein Barr virus (7.7 versus 5.1 percent) or genomically stable (22.5 versus 8.1 percent) subtype. Compared with late-onset gastric cancer, risk factors for gastric cancer were less correlated with early-onset disease.<\/p>\n
“Typically, we see stomach cancer being diagnosed in patients in their 70s, but increasingly we are seeing 30- to 50-year-old patients being diagnosed,” a coauthor said in a statement. “Hopefully, studies like this will raise awareness and increase physician suspicion of stomach cancer, particularly in younger patients.”<\/p>\n
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