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FRIDAY, Dec. 27, 2019 (HealthDay News) — Among obese adolescents with type 2 diabetes, metabolic bariatric surgery is associated with decreased rates of hyperfiltration and elevated urinary albumin excretion (UAE), according to a study published in the January issue of Diabetes Care<\/i>.<\/p>\n
Petter Bjornstad, M.D., from the University of Colorado Anschutz Medical Campus in Aurora, and colleagues performed a secondary analysis of data obtained from obese adolescents. Participants were enrolled in either the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study and underwent metabolic bariatric surgery or the Treatment Options of Type 2 Diabetes in Adolescents and Youth (TODAY) studies and were randomly assigned to metformin alone or in combination with rosiglitazone or intensive lifestyle intervention (30 and 63 participants, respectively).<\/p>\n
The researchers found that hyperfiltration decreased from 21 to 18 percent in Teen-LABS and increased from 7 to 48 percent in TODAY during five years of follow-up. There was a decrease in elevated UAE from 27 to 5 percent in Teen-LABS and an increase from 21 to 43 percent in TODAY. TODAY participants had greater odds of hyperfiltration and elevated UAE at five years of follow-up after adjustment for baseline age, sex, body mass index, and hemoglobin A1c (odds ratios, 15.7 and 27.3, respectively).<\/p>\n
“Surgical treatment of severely obese youth with type 2 diabetes is associated with substantially lower odds of diabetic kidney disease over five years of follow-up compared with standard medical therapy,” the authors write.<\/p>\n
Several pharmaceutical companies provided donations to support the TODAY study.<\/p>\n
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