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THURSDAY, Dec. 26, 2019 (HealthDay News) — A polygenic risk score (PRS), developed from 95 colorectal cancer (CRC)-associated genetic risk variants, is more strongly associated with early- than late-onset cancer, especially in the absence of family history, according to a study published online Dec. 19 in Gastroenterology<\/i>.<\/p>\n
Alexi N. Archambault, M.P.H., from the New York University School of Medicine in New York City, and colleagues examined whether a PRS correlated with the risk for early-onset CRC in 12,197 participants aged younger than 50 years versus 95,865 participants aged 50 years or older. The findings were replicated in 72,573 participants in an independent cohort.<\/p>\n
The researchers found that for early-onset cancer, the overall associations with CRC per standard deviation of PRS were significant and were stronger than late-onset cancer. Comparing the higher versus the lowest PRS quartile, risk increased 3.7-fold and 2.9-fold for early- and late-onset CRC, respectively. Participants without a first-degree family history of CRC had the strongest association. Comparing the highest with the lowest quartiles in this group, risk increased 4.3-fold versus 2.9-fold for early- versus late-onset CRC.<\/p>\n
“The PRS may contribute, along with lifestyle and environmental risk profiling, toward prioritizing individuals at increased susceptibility to early-onset CRC for personalized screening regimens or other intervention strategies,” the authors write. “By selecting high-risk individuals <50 years of age, we can reduce the burden on early detection programs and potentially provide more individualized prevention approaches.\"<\/p>\n
One author was employed by Genentech.<\/p>\n
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