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MONDAY, Dec. 23, 2019 (HealthDay News) — Hypothyroidism is significantly associated with increased all-cause mortality, but not cardiovascular mortality, among the elderly, according to a review published online Dec. 12 in the Journal of Clinical Endocrinology & Metabolism<\/i>.<\/p>\n
Tou-Yuan Tsai, M.D., from the Dalin Tzu Chi Hospital in Chiayi, Taiwan, and colleagues conducted a systematic literature review to identify studies evaluating the association between hypothyroidism and all-cause and\/or cardiovascular mortality among older adults (aged \u226560 years).<\/p>\n
Based on 27 cohort studies (total 1,114,638 participants), the researchers found that patients with hypothyroidism experienced a higher risk for all-cause mortality than those with euthyroidism (pooled relative risk [RR], 1.26; 95 percent confidence interval [CI], 1.15 to 1.37). There was no significant difference in cardiovascular mortality between patients with hypothyroidism and those with euthyroidism (pooled RR, 1.10; 95 percent CI, 0.84 to 1.43). The increased risk for all-cause mortality was associated with overt hypothyroidism (pooled RR, 1.10; 95 percent CI, 1.01 to 1.20) rather than subclinical hypothyroidism (pooled RR, 1.14; 95 percent CI, 0.92 to 1.41). Study heterogeneity resulted from different study designs (prospective and retrospective) and geographic locations (Europe, North America, Asia, and Oceania).<\/p>\n
“Our findings imply that individuals with subclinical hypothyroidism — those who have milder thyroid dysfunction — may not benefit from being treated with synthetic thyroid hormone,” a coauthor said in a statement. “However, treatment should be considered in individuals diagnosed with hypothyroidism, given increased all-cause mortality.”<\/p>\n
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