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WEDNESDAY, Dec. 4, 2019 (HealthDay News) — Elevated concentrations of non-high-density lipoprotein (non-HDL) cholesterol are associated with an increased long-term risk for atherosclerotic cardiovascular disease, according to a study published online Dec. 3 in The Lancet<\/i>.<\/p>\n
Fabian J. Brunner, M.D., from the University Heart & Vascular Center Hamburg in Germany, and colleagues examined the cardiovascular disease risk associated with the spectrum of bloodstream non-HDL cholesterol concentrations. In addition, a tool was created to estimate the probabilities of a cardiovascular disease event by age 75 years.<\/p>\n
A total of 398,846 individuals belonging to 38 cohorts were identified; the derivation and validation cohorts included 199,415 and 199,431 individuals, respectively. The researchers identified 54,542 cardiovascular end points during a maximum follow-up of 43.6 years. For increasing non-HDL cholesterol categories, incidence curve analyses showed progressively higher 30-year cardiovascular disease event rates. For both sexes, in multivariable analysis with non-HDL cholesterol lower than 2.6 mmol\/L as reference, there was an increase noted in the association between non-HDL cholesterol concentration and cardiovascular disease. Cardiovascular disease event probabilities specific for non-HDL cholesterol could be estimated with the derived tool, with high comparability seen between the derivation and validation cohorts. A 50 percent decrease in non-HDL cholesterol concentration correlated with reduced cardiovascular disease event risk by age 75 years; the risk reduction was greater with earlier reductions in cholesterol concentrations.<\/p>\n
“Our study provides unique insights into the benefits of a potential early intervention in primary prevention,” the authors write.<\/p>\n
Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n
Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n