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THURSDAY, Dec. 12, 2019 (HealthDay News) — For patients with early-stage breast cancer, 10-year outcomes are similar for treatment with partial breast irradiation (PBI) and whole breast irradiation (WBI), according to a study presented at the annual San Antonio Breast Cancer Symposium, held from Dec. 10 to 14 in Texas.<\/p>\n
Icro Meattini, M.D., from the University of Florence in Italy, and colleagues presented 10-year follow-up data from the APBI IMRT Florence phase 3 trial. Women aged older than 40 years affected by early breast cancer were randomly assigned to receive either WBI using three-dimensional conformal radiotherapy or accelerated PBI (APBI) using an intensity-modulated radiotherapy technique. Two hundred sixty patients were enrolled in each arm.<\/p>\n
The researchers observed no significant difference in terms of ipsilateral breast tumor recurrence (IBTR) rates between the treatment arms (log rank test, P = 0.58). The five-year and 10-year IBTR rates were 1.96 percent (five events; 95 percent confidence interval [CI], 0.3 to 3.7) and 3.74 percent (nine events; 95 percent CI, 1.5 to 6.3), respectively, in the APBI group compared with 1.2 percent (three events; 95 percent CI, 0 to 2.5) and 2.5 percent (six events; 95 percent CI, 0.7 to 4.5), respectively, for the WBI group. For APBI versus WBI patients, the hazard ratio was 1.33 (95 percent confidence interval, 0.49 to 3.56; P = 0.58). Regarding survival outcomes, there were no significant differences noted between the treatment arms (overall survival, 95.4 percent in APBI versus 94.3 percent in WBI; hazard ratio, 0.66; 95 percent confidence interval, 0.29 to 1.53; P = 0.33).<\/p>\n
“Partial breast irradiation is one of the primary examples of effective de-escalation of treatment in breast oncology,” Meattini said in a statement.<\/p>\n
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