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MONDAY, Nov. 18, 2019 (HealthDay News) — Predictors of attaining low-density lipoprotein cholesterol (LDL-C) and systolic blood pressure (SBP) goals have been identified, according to a study published online Nov. 13 in Circulation: Cardiovascular Quality and Outcomes<\/i>. The research was published to coincide with a presentation of results from the ISCHEMIA study at the American Heart Association, held from Nov. 16 to 18 in Philadelphia.<\/p>\n
Jonathan D. Newman, M.D., M.P.H., from the New York University School of Medicine in New York City, and colleagues determined predictors of meeting trial goals for LDL-C (goal <70 mg\/dL) and SBP (goal <140 mm Hg) at one year after random assignment among individuals in the ISCHEMIA trial. Data were available for 3,984 randomly assigned participants.<\/p>\n
Of the participants, 35 and 65 percent were at goal for LDL-C and SBP, respectively, at baseline, increasing to 52 and 75 percent at one year, respectively. The researchers found increased adjusted odds of one-year LDL-C goal attainment for older age (odds ratio [OR], 1.11 per 10 years), lower baseline LDL-C (OR, 1.19 per 10 mg\/dL), high-intensity statin use (OR, 1.30), nonwhite race (OR, 1.32), and North American enrollment (OR, 1.32). One-year LDL-C goal attainment was less likely for women (OR, 0.68). Greater adjusted odds of one-year SBP goal attainment were seen with lower baseline SBP (OR, 1.27 per 10 mm Hg) and with North American enrollment (OR, 1.35).<\/p>\n
“The relatively modest rates of goal attainment in the setting of a rigorously conducted randomized trial emphasize the need to improve methods to achieve optimal risk factor control for patients with stable ischemic heart disease,” the authors write.<\/p>\n
Arbor Pharmaceuticals and AstraZeneca contributed funding for the study and, together with other pharmaceutical companies, provided device donations and medications.<\/p>\n
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