<\/b><\/p>\n
<\/b><\/p>\n
THURSDAY, Nov. 7, 2019 (HealthDay News) — For severely obese adolescents with type 2 diabetes (T2D), medical therapy is associated with increased odds of diabetic kidney disease (DKD) at five years compared with metabolic bariatric surgery, according to a study published online Nov. 4 in Diabetes Care<\/i>.<\/p>\n
Petter Bjornstad, M.D., from the University of Colorado Anschutz Medical Campus in Aurora, and colleagues conducted a secondary analysis of data collected from obese participants enrolled in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study, who underwent metabolic bariatric surgery, and obese participants enrolled in the Treatment Options of Type 2 Diabetes in Adolescents and Youth (TODAY) study, who were randomly assigned to metformin alone or in combination with rosiglitazone or intensive lifestyle intervention. Thirty participants with T2D from Teen-LABS and 63 from TODAY were compared.<\/p>\n
The researchers found that hyperfiltration decreased from 21 to 18 percent in Teen-LABS and increased from 7 to 48 percent in TODAY during five years of follow-up. In Teen-LABS, elevated urinary albumin excretion (UAE) decreased from 27 to 5 percent, while in TODAY, elevated UAE increased from 21 to 43 percent. At five years of follow-up, TODAY participants had increased odds of hyperfiltration and elevated UAE after adjustment for baseline age, sex, body mass index, and hemoglobin A1c (odds ratios, 15.7 and 27.3, respectively).<\/p>\n
“Surgical treatment of severely obese youth with T2D is associated with substantially lower odds of DKD over five years of follow-up compared with standard medical therapy,” the authors write.<\/p>\n
One author disclosed financial ties to the pharmaceutical industry; the TODAY Study Group received donations from several pharmaceutical companies.<\/p>\n
Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n