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TUESDAY, Feb. 6, 2018 (HealthDay News) — A high advanced glycation end product (H-AGE) diet is associated with decreased vertebral microstructure, mechanical behaviors, and fracture resistance in young female mice, according to a study published recently in the Journal of Bone and Mineral Research<\/i>.<\/p>\n
Svenja Illien-J\u00fcnger, Ph.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues examined whether high dietary AGE ingestion would diminish vertebral structure and function in a sex- and age-dependent manner. Female and male mice were fed low-AGE (L-AGE) or H-AGE diets for six and 18 months, and bone structure and function were measured.<\/p>\n
The researchers observed an increase in AGE levels in serum and cortical vertebrae for 6-month-old H-AGE female mice, while for all animals, blood glucose and body weight remained normal. Six-month-old female mice had inferior vertebral trabecular structure with decreased bone mineral density (BMD) and bone volume fraction when fed an H-AGE diet. Six-month-old H-AGE females had functional deterioration with reduced shear and compression moduli, and maximum load to failure. H-AGE of both sexes had small but significant decreases in cortical BMD and thickness at 18 months, yet functional biomechanical behaviors were not distinguishable from other aging changes.<\/p>\n
“We conclude that an H-AGE diet, without diabetic or overweight conditions, diminished vertebral microstructure, mechanical behaviors, and fracture resistance in young female mice in a manner suggesting accelerated bone aging,” the authors write.<\/p>\n
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