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TUESDAY, Oct. 29, 2019 (HealthDay News) — Aspirin is associated with a reduced rate of aneurysm growth for patients with multiple intracranial aneurysms, according to a review published online Oct. 29 in the Journal of Neurosurgery<\/i>.<\/p>\n
Mario Zanaty, M.D., from the University of Iowa Hospitals and Clinics in Iowa City, and colleagues conducted a retrospective review of a prospectively maintained database to examine whether aspirin is protective against aneurysm growth in patients harboring multiple intracranial aneurysms \u22645 mm. Data were included for 146 patients harboring 375 intracranial aneurysms.<\/p>\n
One hundred forty-six aneurysms were treated at the initial encounter, and 229 aneurysms (2 to 5 mm) were observed. The researchers found that 10.48 percent of the 229 aneurysms grew during the follow-up period; all of these aneurysms later underwent treatment. Rupture did not occur in any of the observed aneurysms. Aspirin was associated with a significantly decreased rate of aneurysm growth in multivariate analysis (odds ratio, 0.19). Hypertension, drug abuse, history of polycystic kidney disease, and subarachnoid hemorrhage at presentation were associated with a significantly increased rate of aneurysm growth (odds ratios, 14.38, 11.26, 9.48, and 5.91, respectively).<\/p>\n
“This study is very promising, as it outlines for the first time the potential therapeutic effect of aspirin in decreasing aneurysm growth. If proven in a larger study, this could offer the first, cheap, effective over-the-counter therapeutic agent that could halt aneurysm growth and prevent rupture,” a coauthor said in a statement. “Many people around the world could benefit from this.”<\/p>\n
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