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WEDNESDAY, Oct. 23, 2019 (HealthDay News) — Ingestion of prescribed blood pressure-lowering medications at bedtime is associated with a reduction in cardiovascular disease (CVD) risk, according to a study published online Oct. 22 in the European Heart Journal<\/i>.<\/p>\n
Ram\u00f3n C. Hermida, Ph.D., from the University of Vigo in Spain, and colleagues conducted a multicenter prospective trial involving 19,084 patients with hypertension who were assigned to ingest the entire daily dose of hypertension medications at bedtime (9,552 patients) or upon awakening (9,532 patients).<\/p>\n
The researchers found that 1,752 participants experienced the primary CVD outcome (CVD death, myocardial infarction, coronary revascularization, heart failure, or stroke) during the 6.3-year median patient follow-up. After adjustment for significant influential characteristics including age, sex, type 2 diabetes, chronic kidney disease, smoking, high-density lipoprotein cholesterol, asleep systolic blood pressure mean, sleep-time relative systolic blood pressure decline, and previous CVD event, patients of the bedtime treatment-time regimen had a lower hazard ratio of the primary CVD outcome (hazard ratio, 0.55) and each of its single components (0.44, 0.66, 0.60, 0.58, and 0.51, respectively) compared with upon-waking treatment time.<\/p>\n
“The results of this study show that patients who routinely take their antihypertensive medication at bedtime, as opposed to when they wake up, have better-controlled blood pressure and, most importantly, a significantly decreased risk of death or illness from heart and blood vessel problems,” Hermida said in a statement.<\/p>\n
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