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THURSDAY, Oct. 10, 2019 (HealthDay News) — For very preterm or very low-birth-weight infants, advancing feeding volume in faster increments versus slower increments is not associated with a difference in survival without moderate or severe neurodevelopmental disability at 24 months, according to a study published in the Oct. 10 issue of the New England Journal of Medicine<\/i>.<\/p>\n
Jon Dorling, M.D., from Dalhousie University in Halifax, Nova Scotia, Canada, and colleagues randomly assigned very preterm or very low-birth-weight infants to daily milk increments of 30 mg\/kg body weight (faster increment, 1,224 infants) or 18 mL\/kg body weight (slower increment, 1,246 infants) until they reached full feeding volumes. Survival without moderate or severe neurodevelopmental disability at 24 months was assessed as the primary outcome.<\/p>\n
The researchers found that the primary outcome occurred in 65.5 and 68.1 percent of infants assigned to the faster- and slower-increment groups, respectively (adjusted risk ratio, 0.96; 95 percent confidence interval, 0.92 to 1.01; P = 0.16). Late-onset sepsis occurred in 29.8 and 31.1 percent of infants in the faster- and slower-increment groups, respectively (adjusted risk ratio, 0.96; 95 percent confidence interval, 0.86 to 1.07). Necrotizing enterocolitis occurred in 5.0 and 5.6 percent of infants in the faster-increment and slower-increment groups, respectively (adjusted risk ratio, 0.88; 95 percent confidence interval, 0.68 to 1.16).<\/p>\n
“The speed of increment in feeding volumes also did not affect the risks of late-onset sepsis, necrotizing enterocolitis, or death during hospitalization,” the authors write.<\/p>\n
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