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THURSDAY, March 22, 2018 (HealthDay News) — Calorie restriction (CR) over two years is associated with considerable weight loss, and with lower than expected energy expenditure (EE) relative to the weight loss, according to a study published online March 22 in Cell Metabolism<\/i>.<\/p>\n
Leanne M. Redman, Ph.D., from the Biochemical Research Center in Baton Rouge, La., and colleagues examined whether EE and its endocrine mediators are reduced with a CR diet over two years in a study involving 34 CR and 10 control non-obese adults.<\/p>\n
The researchers found that about 15 percent CR was achieved over two years, resulting in 8.7 kg average weight loss; controls gained 1.8 kg. EE measured over 24 hours or during sleep in the CR group was about 80 to 120 kcal\/day lower than expected on the basis of weight loss, indicating a sustained metabolic adaptation. Significantly reduced thyroid axis activity and production of reactive oxygen species (F2-isoprostane) accompanied this adaptation.<\/p>\n
“Findings from this two-year CR trial in healthy, non-obese humans provide new evidence of persistent metabolic slowing accompanied by reduced oxidative stress, which supports the rate of living and oxidative damage theories of mammalian aging,” the authors write.<\/p>\n