{"id":25710,"date":"2019-09-26T00:00:00","date_gmt":"2019-09-26T00:00:00","guid":{"rendered":"http:\/\/medgoo.com\/index.php\/2019\/09\/26\/serum-il-35-levels-tied-to-bone-loss-with-rheumatoid-arthritis\/"},"modified":"2019-09-27T16:10:11","modified_gmt":"2019-09-27T16:10:11","slug":"serum-il-35-levels-tied-to-bone-loss-with-rheumatoid-arthritis","status":"publish","type":"post","link":"https:\/\/medgoo.com\/index.php\/2019\/09\/26\/serum-il-35-levels-tied-to-bone-loss-with-rheumatoid-arthritis\/","title":{"rendered":"Serum IL-35 Levels Tied to Bone Loss With Rheumatoid Arthritis"},"content":{"rendered":"<h3>Low BMD, high bone metabolism, low vitamin D also seen in postmenopausal rheumatoid arthritis patients<\/h3>\n<p><b><\/b><\/p>\n<p><b><\/b><\/p>\n<p>THURSDAY, Sept. 26, 2019 (HealthDay News) &#8212; Serum interleukin (IL)-35 levels are associated with bone loss and may represent a novel therapeutic target for postmenopausal women with rheumatoid arthritis (RA), according to a study published online Aug. 26 in <i>Mediators of Inflammation<\/i>.<\/p>\n<p>Yuxuan Li, from the First Affiliated Hospital of China Medical University in Shenyang, and colleagues explored the correlations between IL-35 levels and bone loss in postmenopausal women, including 76 with RA and 53 healthy controls. Additionally, dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) at lumbar spine 1 to 4 and at total hip.<\/p>\n<p>The researchers found that serum IL-35 levels were increased in RA patients compared with healthy controls. Additionally, serum IL-35 level positively correlated with BMD and 25-hydroxyvitamin D3 level and negatively correlated with \u03b2-isomerised carboxy-terminal cross-linking telopeptide of type I collagen in postmenopausal women with RA. Women with higher alkaline phosphatase (ALP) levels had higher serum IL-35 levels than those in the normal ALP group.<\/p>\n<p>&#8220;IL-35, an important anti-inflammatory cytokine, may participate in the pathogenesis of bone loss in postmenopausal women with RA,&#8221; the authors write.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6732582\/\" target=\"_new\" rel=\"noopener noreferrer\">Abstract\/Full Text<\/a><\/p>\n<p><i><\/i><\/p>\n<p><i>Copyright \u00a9 2019 <a href=\"https:\/\/www.healthday.com\/\" target=\"_new\" rel=\"noopener noreferrer\">HealthDay<\/a>. All rights reserved.<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Low BMD, high bone metabolism, low vitamin D also seen in postmenopausal rheumatoid arthritis patients<\/p>\n","protected":false},"author":6,"featured_media":25726,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[11],"class_list":["post-25710","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news"],"_links":{"self":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/25710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/comments?post=25710"}],"version-history":[{"count":0,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/25710\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media\/25726"}],"wp:attachment":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media?parent=25710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/categories?post=25710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/tags?post=25710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}