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THURSDAY, March 22, 2018 (HealthDay News) — Infants given soy-based formula have reproductive system differences compared with those given cow-milk formula or breast milk, according to a study published online March 1 in the Journal of Clinical Endocrinology & Metabolism<\/i>.<\/p>\n
Margaret A. Adgent, Ph.D., from the Vanderbilt University Medical Center in Nashville, Tenn., and colleagues compared estrogen-responsive postnatal development in infants exclusively fed soy formula (102 infants), cow-milk formula (111), or breast milk (70) from birth to 28 weeks in boys or 36 weeks in girls.<\/p>\n
The researchers found that vaginal cell maturation index trended higher and uterine volume decreased more slowly in soy-fed girls versus cow-milk-fed girls. There were, however, no differences in trajectories of breast-bud diameter and hormone concentrations. Estradiol was not detectable and no significant observed differences were seen between boys fed cow-milk formula versus soy formula. Compared to soy-fed infants, breastfed infants differed in vaginal cell maturation index, uterine volume, and girls’ estradiol and boys’ breast-bud diameter trajectories.<\/p>\n
“Relative to cow-milk formula-fed girls, soy formula-fed girls demonstrated tissue and organ-level developmental trajectories consistent with response to exogenous estrogen exposure,” the authors write.<\/p>\n
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