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TUESDAY, Sept. 24, 2019 (HealthDay News) — There is a strong association between 25-hydroxyvitamin D (25[OH]D) deficiency (<50 nmol\/L) and increased mortality, particularly for diabetes-related deaths, according to a study presented at the annual meeting of the European Association for the Study of Diabetes, held from Sept. 16 to 20 in Barcelona, Spain.<\/p>\n
Rodrig Marculescu, M.D., from the Medical University of Vienna, and colleagues linked data from all 78,581 patients (mean age, 51.0 years; men, 31.5 percent) who had a 25(OH)D measurement at the General Hospital of Vienna between 1991 and 2011 to the Austrian national register of deaths.<\/p>\n
During 20 years of follow-up (median, 10.5 years), 11,877 deaths were reported. The researchers found that patients with 25(OH)D \u226410 nmol\/L had a twofold to threefold increased risk for death (<45 years old: hazard ratio [HR], 2.7 [95 percent confidence interval (CI), 2.1 to 3.4]; 45 to <60 years old: HR, 2.9 [95 percent CI, 2.6 to 3.4]; 60 to <75 years old: HR, 2.0 [95 percent CI, 1.8 to 2.3]). Patients with 25(OH)D \u226590 nmol\/L had up to a 40 percent reduction in all-cause mortality (<45 years old: HR, 0.7 [95 percent CI, 0.6 to 0.9]; 45 to <60 years old: HR, 0.6 [95 percent CI, 0.5 to 0.7]; 60 to <75 years old: HR, 0.7 [95 percent CI, 0.7 to 0.8]). No association was noted between 25(OH)D levels in patients \u226575 years (10 nmol\/L: HR, 1.1 [95 percent CI, 1.0 to 1.2]; 90 nmol\/L: HR, 1.0 [95 percent CI, 0.9 to 1.0]). There was a modest relationship between 25(OH)D and either cancer or cardiovascular disease-related mortality, but a stronger association for diabetes-related death (HR, 4.4; 95 percent CI, 3.1 to 6.3).<\/p>\n
“Our findings strengthen the rationale for widespread vitamin D supplementation to prevent premature mortality, emphasize the need for it early in life, and mitigate concerns about a possible negative effect at higher levels,” the authors write.<\/p>\n
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