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THURSDAY, Sept. 5, 2019 (HealthDay News) — Individuals who drink more than six cups of coffee per day have a reduced risk for developing symptomatic gallstone disease (GSD), according to a study published online Sept. 5 in the Journal of Internal Medicine<\/i>.<\/p>\n
A.T. Nordestgaard, from Rigshospitalet in Copenhagen, Denmark, and colleagues examined the correlation between high coffee intake and GSD in 104,493 individuals from the general population during a mean follow-up of eight years. In addition, the researchers examined the correlation of two genetic variants near CYP1A1\/A2<\/i> and AHR<\/i>, combined as an allele score, with higher coffee intake. The correlation between allele score and risk for GSD was examined in 114,220 individuals with 7,294 gallstone events during a mean follow-up of 38 years.<\/p>\n
The researchers found that compared with those without coffee intake, those with coffee intake of more than six cups\/day had a reduced risk for GSD (hazard ratio, 0.77). In genetic analysis, individuals with the highest (four) versus the lowest (zero) coffee intake alleles had a stepwise higher coffee intake of up to 41 percent and a corresponding stepwise lower risk for GSD (hazard ratio, 0.81). For a coffee intake of one cup more per day, the estimated observational odds ratio was 0.97. The corresponding genetic odds ratio was 0.89.<\/p>\n
“These results suggest that high coffee intake is likely to causally protect against symptomatic GSD,” the authors write.<\/p>\n
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