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TUESDAY, Aug. 20, 2019 (HealthDay News) — Lipophilic statin use is associated with significantly reduced hepatocellular carcinoma (HCC) incidence and mortality in adults with chronic viral hepatitis, according to a study published online Aug. 20 in the Annals of Internal Medicine<\/i>.<\/p>\n
Tracey G. Simon, M.D., M.P.H., from Massachusetts General Hospital in Boston, and colleagues examined the correlation between lipophilic or hydrophilic statin use and HCC incidence and mortality in a prospective propensity score-matched cohort of patients 18 years or older with confirmed chronic hepatitis B virus or hepatitis C virus infection. A total of 8,334 adults who initiated statin use (6,554 lipophilic and 1,780 hydrophilic) were matched to 8,334 nonusers.<\/p>\n
The researchers found that lipophilic statin users had a significantly lower 10-year HCC risk compared with matched nonusers (8.1 versus 3.3 percent; absolute risk difference [RD], \u22124.8 percent; adjusted subdistribution hazard ratio [aHR], 0.56; 95 percent confidence interval [CI], 0.41 to 0.79), while hydrophilic statin users did not have a lower risk (8.0 versus 6.8 percent; RD, \u22121.2 percent; aHR, 0.95; 95 percent CI, 0.86 to 1.08). The inverse correlation was dose-dependent; 10-year HCC risk was lowest with 600 or more lipophilic statin cumulative defined daily doses (cDDDs) compared with nonuse (8.4 versus 2.5 percent; RD, \u22125.9 percent; aHR, 0.41; 95 percent CI, 0.32 to 0.61). Both lipophilic and hydrophilic statin users had significantly lower 10-year mortality (15.2 versus 7.3 percent [RD, \u22127.9 percent; 95 percent CI, \u22129.6 to \u22126.2 percent] and 16.0 versus 11.5 percent [RD, \u22124.5 percent; 95 percent CI, \u22126.0 to \u22123.0 percent], respectively).<\/p>\n
“These findings support further research to characterize the potential hepatoprotective benefits of lipophilic statins,” the authors write.<\/p>\n
Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n
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