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MONDAY, Aug. 19, 2019 (HealthDay News) — Mechanical and oral antibiotic bowel preparation (MOABP) does not reduce surgical site infections (SSIs) or the overall morbidity of colon surgery versus no bowel preparation (NBP), according to a study published online Aug. 8 in The Lancet<\/i>.<\/p>\n
Laura Koskenvuo, M.D., from University of Helsinki, and colleagues randomly assigned (1:1) 396 patients undergoing colon resection to either MOABP or NBP in four hospitals in Finland (March 17, 2016, to Aug. 20, 2018). MOABP consisted of drinking 2 liters of polyethylene glycol and 1 liter of clear fluid before 6 p.m. on the day before surgery and taking 2 grams of neomycin orally at 7 p.m. and 2 grams of metronidazole orally at 11 p.m. the day before surgery.<\/p>\n
The researchers found that SSIs were detected in 7 percent of 196 patients assigned to MOABP and in 11 percent of 200 patients assigned to NBP (odds ratio, 1.65; 95 percent confidence interval, 0.80 to 3.40; P = 0.17). Anastomotic dehiscence was reported in 4 percent of both groups. Reoperations were necessary in 8 percent of the MOABP group versus 7 percent of the NBP group. Within 30 days of surgery, two patients died in the NBP group versus none in the MOABP group.<\/p>\n
“We therefore propose that the current recommendations of using MOABP for colectomies to reduce SSIs or morbidity should be reconsidered,” the authors write.<\/p>\n
Two authors disclosed financial ties to pharmaceutical companies.<\/p>\n
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