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WEDNESDAY, Aug. 14, 2019 (HealthDay News) — For children at increased risk, increased gluten intake during the first five years of life is associated with an elevated incidence of celiac disease autoimmunity and celiac disease, according to a study published in the Aug. 13 issue of the Journal of the American Medical Association<\/i>.<\/p>\n
Carin Andr\u00e9n Aronsson, Ph.D., from Lund University in Sweden, and colleagues followed 8,676 newborns carrying human leukocyte antigen genotypes associated with type 1 diabetes and celiac disease. In 6,757 children, screening for celiac disease was performed annually from the age of 2 years; data were available on gluten intake for 6,605 children.<\/p>\n
The researchers found that 18 percent of the 6,605 children developed celiac disease autoimmunity and 7 percent developed celiac disease. For both outcomes, incidence peaked at the age of 2 to 3 years. The risk for celiac disease autoimmunity increased with daily gluten intake (hazard ratio for every 1-g\/day increase in gluten consumption, 1.30; absolute risk by age of 3 years if reference amount of gluten was consumed and gluten intake was 1-g\/day higher than reference, 28.1 and 34.2 percent, respectively; absolute risk difference, 6.1 percent). Daily gluten intake correlated with an increased risk for celiac disease (hazard ratio, 1.50; absolute risks, 20.7 and 27.9 percent, respectively; absolute risk difference, 7.2 percent).<\/p>\n
“Additional studies are needed before a recommendation is made to change the current practice of gluten introduction into a child’s diet,” write the authors of an accompanying editorial.<\/p>\n
Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n