Sex hormone-binding globulin increases inversely linked to CV risk in men with \u22657 percent weight loss<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
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WEDNESDAY, Feb. 4, 2026 (HealthDay News) — In men with type 2 diabetes (T2D), sex hormones are associated with cardiovascular (CV) events, according to a study published online Jan. 26 in Diabetes Care<\/em>.<\/p>\n Teresa Gisinger, M.D., Ph.D., from the Medical University of Vienna, and colleagues examined the association of sex hormones at baseline and one year after a lifestyle intervention on CV risk in a prospective study involving 2,260 adults with T2D.<\/p>\n The researchers found that higher baseline total testosterone was associated with lower CV risk in men (hazard ratio, 0.74). Sex hormone-binding globulin increases were inversely associated with CV risk in men with \u22657 percent weight loss (hazard ratio, 0.47). Increases in estradiol were associated with CV risk in men with <7 percent weight loss (hazard ratios, 1.64 and 1.88, respectively, for second and third versus first estradiol tertile). In women, no associations were seen.<\/p>\n “Results from this study contribute to our understanding of how tracking sex hormones in people with diabetes could complement what we already know about traditional heart disease risk factors [like smoking and cholesterol levels],” lead author Wendy Bennett, M.D., M.P.H., from the Johns Hopkins University School of Medicine in Baltimore, said in a statement. “The results could help clinicians personalize heart disease prevention strategies in the future.”<\/p>\n Two authors disclosed ties to the biopharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n