Stronger associations seen for those with low residential green space exposure or with rs2010352 GG genotype<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
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MONDAY, Jan. 26, 2026 (HealthDay News) — The EAT-Lancet planetary diet, proposed to integrate human health and environmental sustainability, is inversely associated with the risk for incident chronic kidney disease (CKD), according to a study published online Jan. 26 in CMAJ<\/em>, the journal of the Canadian Medical Association.<\/p>\n Sisi Yang, M.D., from Nanfang Hospital in Guangzhou, China, and colleagues examined the association between the EAT-Lancet planetary health diet and the risk for incident CKD using data for 179,508 adult participants from the U.K. Biobank cohort without CKD at baseline. Adherence to the EAT-Lancet diet was assessed using four scoring methods.<\/p>\n The researchers found that 4,819 participants developed incident CKD during a median follow-up of 12.1 years. There was an inverse association between higher EAT-Lancet adherence and CKD risk across all four scoring methods: Stubbendorff, Kesse-Guyot, Yi-Xiang, and Knuppel (adjusted hazard ratios, 0.91, 0.92, 0.94, and 0.94, respectively). Participants with low residential green space exposure and those with the rs2010352 GG genotype showed a stronger association. Significant inverse associations were seen for metabolic and proteomic signatures (122 metabolites and 143 proteins) of the EAT-Lancet diet with CKD risk, and they mediated the inverse association by 18.0 and 27.2 percent, respectively. Degree of fatty acid unsaturation, glycoprotein acetyls, interleukin-18 receptor 1, and kidney injury molecule 1 were key mediators.<\/p>\n “These findings support the adoption of planetary health diets in CKD prevention and underscore the value of personalized nutrition strategies that incorporate genetic, environmental, and molecular profiling,” the authors write.<\/p>\n