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WEDNESDAY, July 31, 2019 (HealthDay News) — Compared with placebo, oral semaglutide monotherapy is associated with superior and clinically relevant improvements in glycated hemoglobin (HbA1c) and weight loss among patients with type 2 diabetes, according to a study published online July 18 in Diabetes Care<\/i>.<\/p>\n
In a phase 3a, randomized, double-blind, placebo-controlled, parallel-group trial, Vanita R. Aroda, M.D., from Brigham and Women’s Hospital in Boston, and colleagues evaluated the safety and efficacy of oral semaglutide, the first oral glucagon-like peptide 1 receptor agonist, as monotherapy in patients with type 2 diabetes managed by diet and exercise alone. The authors randomly assigned (1:1:1:1) 703 patients at 93 international sites to either once-daily oral semaglutide 3 mg, 7 mg, 14 mg, or placebo.<\/p>\n
Over 26 weeks, the researchers found that oral semaglutide reduced HbA1c as well as body weight. The most common adverse events associated with oral semaglutide included mild-to-moderate transient gastrointestinal events. Discontinuation of the trial product occurred in 2.3 to 7.4 percent taking oral semaglutide and 2.2 percent among those taking placebo.<\/p>\n
“Ongoing additional studies in the PIONEER [Peptide Innovation for Early Diabetes Treatment] program will further define its effect when used in combination with other glucose-lowering therapies and in other populations (e.g., in those with high cardiovascular risk or renal impairment) of interest,” the authors write.<\/p>\n
Several authors disclosed financial ties to pharmaceutical companies, including Novo Nordisk, which manufactures semaglutide and funded the study.<\/p>\n
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