<\/b><\/p>\n
<\/b><\/p>\n
TUESDAY, July 30, 2019 (HealthDay News) — Initiation of therapy with sodium-glucose cotransporter-2 (SGLT-2) inhibitors for type 2 diabetes mellitus is not associated with an increased risk for urinary tract infection (UTI) events compared with initiation of other second-line antidiabetic medications, according to a study published online July 30 in the Annals of Internal Medicine<\/i>.<\/p>\n
Chintan V. Dave, Pharm.D., Ph.D., from Brigham and Women’s Hospital in Boston, and colleagues compared the risk for severe UTI events for patients in routine clinical practice initiating SGLT-2 inhibitor use versus those initiating use of dipeptidyl peptidase-4 (DPP-4) inhibitors or glucagon-like peptide-1 receptor (GLP-1) agonists. Within each of two large U.S. commercial claims databases, two cohorts were created and matched in a 1:1 ratio on propensity score. Patients in cohort 1 were initiating use of SGLT-2 inhibitors versus DPP-4 inhibitors (123,752 patients), and those in cohort 2 were initiating use of SGLT-2 inhibitors versus GLP-1 agonists (111,978 patients).<\/p>\n
The researchers found that persons newly receiving SGLT-2 inhibitors had 61 severe UTI events (incidence rate [IR] per 1,000 person-years, 1.76) compared with 57 events in the DPP-4 inhibitor group (IR, 1.77; hazard ratio, 0.98; 95 percent confidence interval, 0.68 to 1.41) in cohort 1. Those receiving SGLT-2 inhibitors in cohort 2 had 73 events compared with 87 events in the GLP-1 agonist group (IR, 2.15 versus 2.96; hazard ratio 0.72; 95 percent confidence interval, 0.53 to 0.99). The researchers noted that the findings were robust across sensitivity analyses.<\/p>\n
“Other factors beyond risk for UTI events should be considered in decisions about whether to prescribe SGLT-2 therapy for patients with diabetes in routine care settings,” the authors write.<\/p>\n
Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n
Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n