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FRIDAY, July 26, 2019 (HealthDay News) — Vitamin D3<\/sub> supplementation can improve glucose metabolism in patients at high risk of diabetes or with newly-diagnosed diabetes, according to a study published online July 1 in the European Journal of Endocrinology<\/i>.<\/p>\n Patricia Lemieux, from the Universit\u00e9 Laval in Qu\u00e9bec City, and colleagues conducted a single-center, double-blind, placebo-controlled trial involving 96 participants at high risk of diabetes or with newly-diagnosed type 2 diabetes. Participants were randomly assigned to either six months of 5,000 IU vitamin D3<\/sub> daily or placebo.<\/p>\n The researchers found that the mean 25-hydroxyvitamin D level reached 127.6 \u00b1 26.3 nmol\/L and 51.8 \u00b1 16.5 nmol\/L in the treatment and placebo groups, respectively, at six months. Compared with placebo, vitamin D3<\/sub> had a beneficial effect on peripheral insulin sensitivity (mean change, 0.92 versus \u22120.03) and disposition index (mean change, 267.0 versus \u221255.5) after six months.<\/p>\n “The reason we saw improvements in glucose metabolism following vitamin D supplementation in those at high risk of diabetes, or with newly-diagnosed diabetes, while other studies failed to demonstrate an effect in people with long-standing type 2 diabetes is unclear,” a coauthor said in a statement. “This could be due to the fact that improvements in metabolic function are harder to detect in those with longer-term disease or that a longer treatment time is needed to see the benefit.”<\/p>\n Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n