<\/b><\/p>\n
<\/b><\/p>\n
THURSDAY, July 18, 2019 (HealthDay News) — Both systolic and diastolic hypertension contribute independently to the risk for adverse cardiovascular events, according to a study published in the July 18 issue of the New England Journal of Medicine<\/i>.<\/p>\n
Alexander C. Flint, M.D., Ph.D., from Kaiser Permanente Northern California in Oakland, and colleagues used data from 1.3 million adults in a general outpatient population to examine the effect of the burden of systolic and diastolic hypertension on a composite outcome of myocardial infarction, ischemic stroke, or hemorrhagic stroke during eight years.<\/p>\n
The researchers found that adverse outcomes were independently predicted by the burdens of systolic and diastolic hypertension. A continuous burden of systolic hypertension (\u2265140 mm Hg) and diastolic hypertension (\u226590 mm Hg) independently predicted the composite outcome in survival models (hazard ratio per unit increase in z score, 1.18 and 1.06, respectively). The results were similar with lower thresholds of hypertension (\u2265130\/80 mm Hg) and with systolic and diastolic blood pressures used as predictors without hypertension thresholds. There was a J-curve relation between diastolic blood pressure and outcomes; this finding was partially explained by age and other covariates and by a higher effect of systolic hypertension among individuals in the lowest diastolic blood pressure quartile.<\/p>\n
“Both systolic and diastolic hypertension contribute significantly to cardiovascular risk, regardless of the threshold used for hypertension (\u2265140\/90 mm Hg or \u2265130\/80 mm Hg),” the authors write.<\/p>\n
Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n