Review of randomized controlled trials shows interventions improve psoriasis severity and quality of life<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
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MONDAY, Dec. 29, 2025 (HealthDay News) — Weight-loss interventions seem to improve psoriasis severity and quality of life, according to a review published online Dec. 19 in the Journal of the European Academy of Dermatology and Venerology<\/em>.<\/p>\n Sarah Morrow, B.M., B.Ch., from the University of Oxford in the United Kingdom, and colleagues examined the impact of weight-loss interventions on psoriasis severity and quality of life. Five databases and two trial registries were systematically searched. Patient focus-group discussions informed outcomes. The review included randomized controlled trials (RCTs) in adults with psoriasis, comparing any weight-loss intervention to usual care or a lower-intensity weight-loss intervention; 13 RCTs (1,145 participants), with 14 comparisons, were reviewed.<\/p>\n Eleven interventions advised dietary changes, and of these interventions, four included physical activity; three used weight-loss medications. The researchers found that weight-loss interventions produced a greater reduction in the Psoriasis Area and Severity Index (PASI) than control across 14 interventions (mean difference, \u22122.5). A significant effect of weight-loss interventions was seen on the likelihood of achieving a 75 percent reduction in baseline PASI (PASI75). The intervention had no significant effect on the likelihood of achieving PASI50 or PASI100; both analyses were limited by few studies. Weight-loss interventions were associated with a significant improvement in the Dermatology Life Quality Index compared with control across seven comparisons (mean difference, \u22125.0).<\/p>\n “Clinicians should consider using these findings to counsel patients and refer them for weight-loss support when appropriate,” the authors write.<\/p>\n Several authors disclosed ties to the pharmaceutical industry.<\/p>\n