{"id":22495,"date":"2019-07-09T00:00:00","date_gmt":"2019-07-09T00:00:00","guid":{"rendered":"http:\/\/medgoo.com\/index.php\/2019\/07\/09\/simple-fixed-threshold-ids-those-at-risk-for-copd-related-events\/"},"modified":"2019-07-10T16:07:58","modified_gmt":"2019-07-10T16:07:58","slug":"simple-fixed-threshold-ids-those-at-risk-for-copd-related-events","status":"publish","type":"post","link":"https:\/\/medgoo.com\/index.php\/2019\/07\/09\/simple-fixed-threshold-ids-those-at-risk-for-copd-related-events\/","title":{"rendered":"Simple Fixed Threshold IDs Those at Risk for COPD-Related Events"},"content":{"rendered":"<h3>FEV<sub>1<\/sub>:FVC of 0.70 not significantly different from optimal threshold, better than LLN threshold<\/h3>\n<p><b><\/b><\/p>\n<p><b><\/b><\/p>\n<p>TUESDAY, July 9, 2019 (HealthDay News) &#8212; Use of a threshold of airflow obstruction of forced expiratory volume in one second:forced vital capacity (FEV<sub>1<\/sub>:FVC) of 0.70 discriminates chronic obstructive pulmonary disease (COPD)-related hospitalization and mortality, according to a study published in the June 25 issue of the <i>Journal of the American Medical Association<\/i>.<\/p>\n<p>Surya P. Bhatt, M.D., from the University of Alabama at Birmingham, and colleagues examined the discriminative accuracy of various FEV<sub>1<\/sub>:FVC fixed thresholds for predicting COPD-related hospitalization and mortality using pooled data for 24,207 adults from four U.S. cohorts. Complete data were available for 11,077 individuals at 15 years.<\/p>\n<p>The researchers found that 3,925 participants experienced COPD-related events during 340,757 person-years of follow-up, including 3,563 COPD-related hospitalizations and 447 COPD-related deaths. With respect to discrimination of COPD-related events, the investigators found no significant difference between the optimal fixed threshold (0.71; C-statistic, 0.696) and the 0.70 threshold (difference, 0.001; 95 percent confidence interval, \u22120.002 to 0.004); however, the optimal fixed threshold was more accurate than the lower limit of normal threshold (difference, 0.034; 95 percent confidence interval, 0.028 to 0.041). In the subgroup analysis of ever smokers and in adjusted models, the 0.70 threshold provided optimal discrimination.<\/p>\n<p>&#8220;We were able to show that a simple fixed threshold worked well in our study&#8217;s very diverse sample, which improves the generalizability of our results,&#8221; a coauthor said in a statement.<\/p>\n<p>Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n<p><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/article-abstract\/2736562\" target=\"_new\" rel=\"noopener noreferrer\">Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n<p><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/article-abstract\/2736536\" target=\"_new\" rel=\"noopener noreferrer\">Editorial (subscription or payment may be required)<\/a><\/p>\n<p><i><\/i><\/p>\n<p><i>Copyright \u00a9 2019 <a href=\"https:\/\/www.healthday.com\/\" target=\"_new\" rel=\"noopener noreferrer\">HealthDay<\/a>. All rights reserved.<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>FEV<sub>1<\/sub>:FVC of 0.70 not significantly different from optimal threshold, better than LLN threshold<\/p>\n","protected":false},"author":6,"featured_media":22537,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[11],"class_list":["post-22495","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news"],"_links":{"self":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/22495","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/comments?post=22495"}],"version-history":[{"count":0,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/22495\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media\/22537"}],"wp:attachment":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media?parent=22495"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/categories?post=22495"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/tags?post=22495"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}