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FRIDAY, June 28, 2019 (HealthDay News) — Morning preference seems to have a protective effect on breast cancer risk, according to a study published online June 26 in The BMJ<\/i>.<\/p>\n
Rebecca C. Richmond, Ph.D., from the University of Bristol in the United Kingdom, and colleagues examined whether sleep traits have a causal effect on the risk for breast cancer using data from the U.K. Biobank prospective cohort study and the Breast Cancer Association Consortium (BCAC) case-control genome-wide association study. Data were included for 156,848 women in the U.K. Biobank (7,784 with a breast cancer diagnosis) and 122,977 cases and 105,974 controls from the BCAC.<\/p>\n
The researchers found that morning preference was inversely associated with breast cancer in multivariable regression analysis using U.K. Biobank data (hazard ratio, 0.95), while there was little evidence for a correlation for sleep duration and insomnia symptoms. One-sample mendelian randomization (MR) analysis of U.K. Biobank data provided some supportive evidence for a protective effect of morning preference using 341 single nucleotide polymorphisms associated with chronotype, 91 associated with sleep duration, and 57 associated with insomnia symptoms. Two-sample MR using data from the BCAC indicated a protective effect for morning preference (inverse variance weighted odds ratio, 0.88 per category increase) and an adverse effect of increased sleep duration (1.19 per hour increase) on breast cancer risk.<\/p>\n
“These findings have potential implications for influencing sleep habits of the general population to improve health,” the authors write.<\/p>\n
Two authors disclosed ties to the biopharmaceutical and medical device industries.<\/p>\n
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