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WEDNESDAY, June 26, 2019 (HealthDay News) — Intake of linoleic acid (LA) is inversely associated with the risk for type 2 diabetes, according to a study published in the June issue of Diabetes Care<\/i>.<\/p>\n
Geng Zong, Ph.D., from the Chinese Academy of Sciences in China, and colleagues used data from 83,648 women participating in the Nurses’ Health Study (NHS; 1980-2012), 88,610 women from NHSII (1991-2013), and 41,771 men from the Health Professionals Follow-Up Study (1986-2012) to examine the association between intakes of n-6 polyunsaturated fatty acids (PUFAs) and type 2 diabetes risk. There were 18,442 type 2 diabetes cases during 4.93 million person-years of follow-up.<\/p>\n
Dietary n-6 PUFAs accounted for an average of 4.4 percent to 6.8 percent of total energy and consisted primarily of linoleic acid (at least 98 percent). When extreme n-6 PUFA quintiles (highest versus lowest) were compared in multivariate-adjusted models, the hazard ratio for type 2 diabetes risk was 0.91 (Ptrend<\/sub> = 0.002) for total n-6 PUFAs and 0.92 (Ptrend<\/sub> = 0.01) for LA. In a model allowing for isocaloric substitution, type 2 diabetes risk was 14 percent lower when LA isocalorically replaced saturated fats (5 percent of energy; P = 0.002), 17 percent lower when substituting for trans fats (2 percent energy; P < 0.0001), and 9 percent lower when substituting for carbohydrates (5 percent energy; P = 0.047). There was no impact on diabetes risk when n-3 PUFAs or monounsaturated fats were replaced with LA.<\/p>\n “Our study provides additional evidence that LA intake is inversely associated with risk of type 2 diabetes, especially when replacing saturated fatty acids, trans fats, or carbohydrates,” the authors write.<\/p>\n Several authors disclosed ties to Unilever, and one disclosed ties to the California Walnut Commission.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n