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THURSDAY, June 13, 2019 (HealthDay News) — For Chinese postmenopausal women, vitamin D (VitD) and estradiol (E2<\/sub>) deficiency have a synergistic effect on metabolic syndrome (MetS), according to a study published online June 10 in Menopause<\/i>.<\/p>\n Hui Huang, M.D., from Sun Yat-Sen University in Guangzhou, China, and colleagues examined 616 postmenopausal women from southern China who were not taking estrogen or VitD\/calcium supplements in a cross-sectional study. For each participant, serum E2<\/sub> and 25-hydroxyvitamin D (25[OH]D) were measured.<\/p>\n The researchers identified a positive correlation between 25(OH)D and E2<\/sub>. There was a correlation for higher 25(OH)D with a favorable lipid profile, blood pressure, and glucose level. There was a negative association for E2<\/sub> with cholesterol, triglycerides, and blood pressure. After multivariable adjustment, the odds ratio for MetS was 2.19 for VitD-deficient versus VitD-sufficient women. After further adjustment for E2<\/sub> levels, this association persisted. Low E2<\/sub> increased MetS risk in women with VitD deficiency after stratified analysis by VitD status (odds ratio, 3.49 for the lowest versus highest tertile).<\/p>\n “This study emphasizes the possible synergistic roles of VitD and E2<\/sub> deficiency in developing MetS in postmenopausal women,” the authors write. “Prospective and interventional studies are further needed to confirm this cross-sectional association.”<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n