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WEDNESDAY, June 12, 2019 (HealthDay News) — For patients with stage III or IVA endometrial cancer, chemotherapy plus radiation is not associated with improved relapse-free survival versus chemotherapy alone, according to a study published in the June 13 issue of the New England Journal of Medicine<\/i>.<\/p>\n
Daniela Matei, M.D., from Northwestern University in Chicago, and colleagues randomly assigned 707 patients with stage III or IVA endometrial carcinoma to six months of platinum-based chemotherapy plus radiation therapy (chemoradiotherapy; 346 patients) or six cycles of combination chemotherapy alone (361 patients). Patients were followed for a median of 47 months for the primary end point of relapse-free survival.<\/p>\n
The researchers found that the Kaplan-Meier estimate of the percentage of patients alive and relapse-free was 59 and 58 percent in the chemoradiotherapy and chemotherapy-alone groups, respectively (hazard ratio [HR], 0.90; 95 percent confidence interval [CI], 0.74 to 1.10). Compared with chemotherapy alone, chemoradiotherapy correlated with a lower five-year incidence of vaginal recurrence (2 versus 7 percent; HR, 0.36; 95 percent CI, 0.16 to 0.82) and pelvic and paraaortic lymph-node recurrence (11 versus 20 percent; HR, 0.43; 95 percent CI, 0.28 to 0.66), while distant recurrence was more common with chemoradiotherapy (27 versus 21 percent; HR, 1.36; 95 percent CI, 1.00 to 1.86).<\/p>\n
“Our results indicate the combined regimen of radiation and chemotherapy did not result in an improvement in recurrence-free survival, and that chemotherapy alone remains the standard of care for stage III uterine cancer,” Matei said in a statement.<\/p>\n
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