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WEDNESDAY, March 14, 2018 (HealthDay News) — Surgical treatment of severe obesity in adolescents with type 2 diabetes is associated with better glycemic control and weight reduction than medical therapy, according to a study published online March 12 in JAMA Pediatrics<\/i>.<\/p>\n
Thomas H. Inge, M.D., Ph.D., from the University of Colorado Denver in Aurora, and colleagues compared glycemic control in cohorts of severely obese adolescents with type 2 diabetes undergoing medical and surgical interventions. Data were obtained for participants in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS), who underwent a primary bariatric surgical procedure, and the Treatment Options of Type 2 Diabetes in Adolescents and Youth (TODAY) consortia, who were randomized to metformin alone or in combination with rosiglitazone or an intensive lifestyle intervention. Data from 30 Teen-LABS participants and 63 TODAY participants were analyzed.<\/p>\n
The researchers found that the mean hemoglobin A1c concentration decreased from 6.8 to 5.5 percent in Teen-LABS and increased from 6.4 to 7.8 percent in TODAY participants during two years. In Teen-LABS there was a 29 percent decrease in body mass index compared with baseline, while a 3.7 percent increase was seen in TODAY. During two-year follow-up, 23 percent of Teen-LABS participants required a subsequent operation.<\/p>\n
“These data support the need for a well-designed, prospective controlled study to define the role of surgery for adolescents with type 2 diabetes, including health and surgical outcomes,” the authors write.<\/p>\n
Several authors disclosed financial ties to the pharmaceutical and weight loss industries.<\/p>\n
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