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WEDNESDAY, May 22, 2019 (HealthDay News) — Laser interstitial thermal therapy (LITT) targeting greater amygdala volume is more likely to be associated with Engel I outcomes for mesial temporal lobe epilepsy (mTLE), according to a study published online May 21 in Epilepsia<\/i>.<\/p>\n
Chengyuan Wu, M.D., from the Vickie and Jack Farber Institute for Neuroscience at Thomas Jefferson University in Philadelphia, and colleagues conducted a multicenter cohort study involving 234 patients from 11 centers who underwent LITT for mTLE. The correlation of clinical variables and ablation location to seizure outcome was calculated.<\/p>\n
The researchers found that Engel I outcomes were more likely to be associated with ablations including more anterior, medial, and inferior temporal lobe structures, which involved greater amygdalar volume. Fifty-eight percent of participants achieved Engel I outcomes at both one and two years after LITT. The chances of Engel I outcome were decreased with a history of bilateral tonic-clonic seizures. There was no correlation for radiographic hippocampal sclerosis with seizure outcome.<\/p>\n
“These studies are helping us provide patients with a surgical option that is less invasive — and these results bring us closer to outcomes similar to open-brain surgery in properly selected patients,” Wu said in a statement. “We’ve shown that some areas are not as effective targets as others, which means we can ablate less to get the same results, with fewer side effects.”<\/p>\n
Several authors disclosed financial ties to the pharmaceutical and medical technology industries.<\/p>\n
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