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WEDNESDAY, May 22, 2019 (HealthDay News) — Substantial weight loss before deceased donor kidney transplantation (DDKT) is associated with worse outcomes among DDKT recipients, according to a study published online May 21 in the American Journal of Kidney Diseases<\/i>.<\/p>\n
Meera Nair Harhay, M.D., from the Drexel University College of Medicine in Philadelphia, and colleagues conducted a retrospective cohort study for all adult DDKT recipients in the United States between Dec. 4, 2004, and Dec. 3, 2014. The authors examined the correlation between relative pre-DDKT weight change and three outcomes: transplant hospitalization length of stay (LOS), all-cause graft failure, and mortality.<\/p>\n
The researchers found a median pre-DDKT weight change of 0 among 94,465 recipients of DDKT. Nonlinear unadjusted associations were identified between relative pre-DDKT weight loss and longer hospitalization LOS, higher graft loss, and higher mortality. Recipients who lost \u226510 percent of their listing weight compared with those with a pre-DDKT weight change <5 percent had an average 0.66 days longer transplant hospitalization LOS and higher graft loss and mortality (adjusted hazard ratios, 1.11 and 1.18, respectively), independent of recipient, donor, and transplant factors.<\/p>\n
“Without closely monitoring changes in body composition, ‘successful’ weight loss in an obese patient could cause a physician to overlook what would otherwise be a warning sign,” Harhay said in a statement. “Our work suggests that we need to be cautious when our patients are losing weight, regardless of body mass index.”<\/p>\n
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