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TUESDAY, March 13, 2018 (HealthDay News) — A magnetically levitated centrifugal continuous-flow circulatory pump is superior to a mechanical-bearing axial continuous-flow pump at two years for patients with advanced heart failure, according to a study published online March 11 in the New England Journal of Medicine<\/i>. The research was published to coincide with the annual meeting of the American College of Cardiology, held from March 10 to 12 in Orlando, Fla.<\/p>\n
Mandeep R. Mehra, M.D., from the Brigham and Women’s Hospital in Boston, and colleagues conducted a randomized noninferiority and superiority trial comparing the centrifugal-flow pump (190 patients) with the axial-flow pump (176 patients) in patients with advanced heart failure.<\/p>\n
The researchers found that the primary end point (composite of survival at two years free of disabling stroke or survival free of reoperation to replace or remove a malfunctioning device) occurred in 79.5 and 60.2 percent of the centrifugal-flow and axial-flow pump groups, respectively (absolute difference, 19.2 percentage points; 95 percent lower confidence boundary, 9.8 percentage points [P < 0.001 for noninferiority]; hazard ratio, 0.46; 95 percent confidence interval, 0.31 to 0.69 [P < 0.001 for superiority]). Compared with the axial-flow pump group, the centrifugal-flow group had significantly less frequent reoperation for pump malfunction.<\/p>\n
“In patients with advanced heart failure, a fully magnetically levitated centrifugal-flow pump was superior to a mechanical-bearing axial-flow pump with regard to survival free of disabling stroke or reoperation to replace or remove a malfunctioning device,” the authors write.<\/p>\n
The study was funded by Abbott.<\/p>\n
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