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FRIDAY, May 10, 2019 (HealthDay News) — Isradipine does not appear to slow progression of disability in patients with de novo Parkinson disease (PD), according to a study presented at the annual meeting of the American Academy of Neurology, held from May 4 to 10 in Philadelphia.<\/p>\n
Tanya Simuni, M.D., from the Northwestern University Feinberg School of Medicine in Chicago, conducted a 36-month study to assess the efficacy of isradipine (10 mg daily) versus placebo for slowing progression of disability in de novo PD. A total of 336 participants were enrolled, with study retention of 95 percent.<\/p>\n
The researchers found that the adjusted mean Unified Parkinson Disease Rating Scale (UPDRS) Part I to III score changes measured in the ON state at 36 months were 2.99 and 3.26 points in the isradipine and placebo groups, respectively, with a treatment effect of 0.27 points (95 percent confidence interval, \u22122.5 to 3.0; P = 0.85). No effect was seen for isradipine treatment in the key secondary outcomes in change in UPDRS-III in the OFF state, time to initiation and utilization of dopaminergic therapy, time to onset of motor complications, change in nonmotor disability, and quality-of-life measures. Edema was the most notable side effect of isradipine.<\/p>\n
“Of course, this is disappointing news for everyone with Parkinson disease and their families, as well as the research community,” Simuni said in a statement. “However, negative results are important because they provide a clear answer, especially for the drug that is commercially available. We will all continue to work to find a treatment that can slow down or even cure this disease.”<\/p>\n
Simuni disclosed financial ties to the pharmaceutical industry.<\/p>\n
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