Similar safety profile seen in children with mild asthma aged 5 to 15 years<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b>
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WEDNESDAY, Oct. 8, 2025 (HealthDay News) — In children aged 5 to 15 years with mild asthma, budesonide-formoterol reliever monotherapy is superior to salbutamol for preventing asthma attacks, according to a study published in the Oct. 4 issue of The Lancet<\/em>.<\/p>\n Lee Hatter, M.D., from the Medical Research Institute of New Zealand in Wellington, and colleagues compared the efficacy of combination inhaled corticosteroid-formoterol reliever monotherapy versus short-acting \u03b22-agonist (SABA) reliever monotherapy on the rate of asthma attacks in children. The analysis included 360 children (aged 5 to 15 years) with mild asthma who were randomly assigned in a 1:1 fashion to either budesonide 50 \u00b5g-formoterol 3 \u00b5g, two actuations as needed (179 participants), or salbutamol 100 \u00b5g, two actuations as needed (181 participants).<\/p>\n The researchers found that the annualized rate of asthma attacks was lower in the budesonide-formoterol group than in the salbutamol group (cluster-adjusted rates, 0.23 versus 0.41 per participant per year [relative rate, 0.55; 95 percent confidence interval (CI), 0.35 to 0.86; P = 0.012]). The number of participants with at least one adverse event was similar between the groups (91 percent in the budesonide-formoterol group and 92 percent in the salbutamol group; odds ratio, 0.79; 95 percent CI, 0.35 to 1.79).<\/p>\n “This is a key step in addressing the evidence gap that exists between asthma management in adults and children,” Hatter in a statement. “For the first time, we have demonstrated that the budesonide-formoterol 2-in-1 inhaler, used as needed for symptom relief, can significantly reduce asthma attacks in children with mild asthma. This evidence-based treatment could lead to improved asthma outcomes for children worldwide.”<\/p>\n One author disclosed ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n