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MONDAY, April 15, 2019 (HealthDay News) — Normalized blood pressure (BP) is associated with an increased risk for all-cause mortality for older adults during hypertension treatment, with increased risk seen in octogenarians and those with previous cardiovascular events, according to a study recently published in the European Heart Journal<\/i>.<\/p>\n
Antonios Douros, M.D., from the Universit\u00e4tmedizin Berlin, and colleagues examined the correlation of BP values less than 140\/90 mm Hg during antihypertensive treatment with the risk for all-cause mortality in a cohort of 1,628 patients aged \u226570 years.<\/p>\n
The researchers found that 636 of the patients exhibited normalized BP. Overall, 469 patients died during 8,853 person-years of follow-up. Normalized BP (<140\/<90 mm Hg) correlated with an increased risk for all-cause mortality compared with non-normalized BP (\u2265140\/\u226590 mm Hg; incidence rates, 60.3 versus 48.5 per 1,000 person-years; hazard ratio, 1.26). Risks were increased in patients aged \u226580 years (102.2 versus 77.5 per 1,000 person-years; hazard ratio, 1.40) and in patients with previous cardiovascular events (98.3 versus 63.6 per 1,000 person-years; hazard ratio, 1.61). Risks were not increased among patients aged 70 to 79 years or for those without previous cardiovascular events.<\/p>\n
“Given the scarcity of randomized controlled trials in elderly populations and the challenges regarding the generalization of their results in real-world clinical practice, careful individualized clinical assessment of potential benefits, and harms of antihypertensive treatment should guide physician decision-making,” the authors write.<\/p>\n
Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n
Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n